Results
| PMID | 15958314 |
| Gene Name | NFKB1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 159 |
| Population details | 159 (35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis, 76 ectopic endometrium) |
| Sex | Female |
| Associated genes | NF-kappaB, VEGF |
| Other associated phenotypes |
Endometriosis |
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Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun;25(6):703-5. Wang, Fang| He, Yuan-li| Peng, Dong-xian| Liu, Mu-biao Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. wangfang1973_8@hotmail.com OBJECTIVE: To investigate the association of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis. METHODS: Immunohistochemistry was used to examine the NF-kappaB and VEGF protein expression in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically. RESULTS: The expressions of NF-kappaB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-kappaB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01). CONCLUSION: NF-kappaB and ICAM-1 may participate in the process of the pathogenesis in endometriosis. Mesh Terms: Endometriosis/*metabolism| Female| Humans| Immunohistochemistry| Intercellular Adhesion Molecule-1/*biosynthesis/genetics| NF-kappa B/*biosynthesis/genetics| Vascular Endothelial Growth Factor A/biosynthesis/genetics|DA 2007/06/15 09:00 |
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